| Year | Vaccine |
| 1796 | Edward Jenner develops and documents first vaccine for smallpox. |
| 1880 | First vaccine for cholera by Louis Pasteur |
| 1885 | First vaccine for rabies by Louis Pasteur and Émile Roux |
| 1890 | First vaccine for tetanus (serum antitoxin) by Emil von Behring |
| 1896 | First vaccine for typhoid fever by Almroth Edward Wright, Richard Pfeiffer, and Wilhelm Kolle |
| 1897 | First vaccine for bubonic plague by Waldemar Haffkine |
| 1921 | First vaccine for tuberculosis by Albert Calmette |
| 1923 | First vaccine for diphtheria by Gaston Ramon, Emil von Behring and Kitasato Shibasaburō |
| 1924 | First vaccine for scarlet fever by George F. Dick and Gladys Dick |
| 1924 | First inactive vaccine for tetanus (tetanus toxoid, TT) by the French Gaston Ramon, C. Zoeller and P. Descombey |
| 1926 | First vaccine for pertussis (whooping cough) by Leila Denmark |
| 1932 | First vaccine for yellow fever by Max Theiler and Jean Laigret |
| 1937 | First vaccine for typhus by Rudolf Weigl, Ludwik Fleck and Hans Zinsser |
| 1937 | First vaccine for influenza by Anatol Smorodintsev |
| 1941 | First vaccine for tick-borne encephalitis |
| 1952 | First vaccine for polio (Salk vaccine) |
| 1954 | First vaccine for Japanese encephalitis |
| 1954 | First vaccine for anthrax |
| 1957 | First vaccine for adenovirus-4 and 7 |
| 1962 | First oral polio vaccine (Sabin vaccine) |
| 1963 | First vaccine for measles |
| 1967 | First vaccine for mumps |
| 1970 | First vaccine for rubella |
| 1977 | First vaccine for pneumonia (Streptococcus pneumoniae) |
| 1978 | First vaccine for meningitis (Neisseria meningitidis) |
| 1980 | Smallpox declared eradicated worldwide due to vaccination efforts |
| 1981 | First vaccine for hepatitis B (first vaccine to target a cause of cancer) |
| 1984 | First vaccine for chicken pox |
| 1985 | First vaccine for Haemophilus influenzae type b (HiB) |
| 1989 | First vaccine for Q fever |
| 1990 | First vaccine for Hantavirus hemorrhagic fever with renal syndrome |
| 1991 | First vaccine for hepatitis A |
| 1998 | First vaccine for Lyme disease |
| 1998 | First vaccine for rotavirus |
| 2003 | First nasal influenza vaccine approved in U.S. (FluMist) |
| 2003 | First vaccine for Argentine hemorrhagic fever. |
| 2006 | First vaccine for human papillomavirus (which is a cause of cervical cancer) |
| 2012 | First vaccine for hepatitis E |
| 2012 | First quadrivalent (4-strain) influenza vaccine |
| 2015 | First vaccine for enterovirus 71, one cause of hand foot mouth disease |
| 2015 | First vaccine for malaria |
| 2015 | First vaccine for dengue fever |
| 2019 | First vaccine for Ebola approved |
| 2020 | First vaccine for COVID-19. |
