Scientist a synthetic molecule to quell allergy

November 2, 2012

Scientists have discovered that a new synthetic molecule named “DARP E2-79” could pave the way for quick-acting remedies for a number of acute allergic reactions.

What is Allergy?

Allergy is a hypersensitivity disorder of immune system. These reactions occur when a person’s immune system reacts to normally harmless substances in the environment. The substance which incites such a reaction is called an allergen. These reactions are acquired, predictable, and rapid. When exposed to the allergen, the immune system produces a type of antibody (IgE). IgE incites certain cells in our body (mast cells and basophils) to produce chemical called histamine. Histamine is what is responsible for the symptoms of your allergy.

How can “DARP E2-79” help?

In order to trigger an allergic response, antiboby IgE needs to bind with a specific receptor called FcR. FcR is a protein found on the surface of certain cells including mast cells, immune cells present in the nasal lining and in the eyelids, along with IgE. Here works DARP E2-79, which detaches IgE from its partner FcR, thereby turning the process off.

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