1. Which institute has proposed a mission called PRATUSH to study the Cosmic Dawn?
[A] Raman Research Institute (RRI), Bengaluru
[B] Physical Research Laboratory (PRL), Ahmedabad
[C] Indian Institute of Astrophysics (IIA), Bengaluru
[D] None of the Above
Show Answer
Correct Answer: A [Raman Research Institute (RRI), Bengaluru]
Notes:
Scientists at Raman Research Institute (RRI) proposed a mission called PRATUSH to study the Cosmic Dawn. PRATUSH stands for Probing ReionizATion of the Universe using Signal from Hydrogen. It is a radio telescope to be placed on the far side of the Moon. It is built by Raman Research Institute (RRI) Bengaluru with collaboration from Indian Space Research Organisation (ISRO). It will use a wideband antenna (30–250 MHz), a self-calibratable analog receiver, and a digital correlator with 100 kHz spectral resolution. It will observe large sky regions continuously and record spectra of radio emission. Its nominal lifetime is two years to collect high-quality data.
2. Which institute discovered that protein p47 acts as a “mechanical chaperone”, enhancing protein stability under mechanical stress?
[A] Indian Institute of Science (IISc), Bengaluru
[B] S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata
[C] National Chemical Laboratory (NCL), Pune
[D] Centre for Cellular and Molecular Biology (CCMB), Hyderabad
Show Answer
Correct Answer: B [S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata]
Notes:
Researchers at S. N. Bose National Centre for Basic Sciences (SNBNCBS) discovered protein p47’s new role as a “mechanical chaperone.” P47 is a cofactor protein known for assisting p97 in protein trafficking, degradation, and membrane fusion. Study revealed p47 boosts mechanical efficiency of protein extraction from endoplasmic reticulum (ER) to cytoplasm. It stabilizes polypeptides under stress, guides them through pores, prevents misfolding, and improves translocation. This is the first single-molecule evidence of autonomous, force-dependent chaperone-like activity by p47. Discovery opens new therapeutic possibilities for diseases linked to protein instability.
3. Which organization developed India’s first indigenous multi-stage malaria vaccine (AdFalciVax)?
[A] Indian Council of Medical Research (ICMR)
[B] National Institute of Virology (NIV)
[C] All India Institute of Medical Sciences (AIIMS) New Delhi
[D] Serum Institute of India
Show Answer
Correct Answer: A [Indian Council of Medical Research (ICMR)]
Notes:
India has licensed Indian Immunologicals Limited, Techinvention Lifecare Private Limited, Panacea Biotec Limited, Biological E Limited, and Zydus Lifesciences for manufacturing its first indigenous multi-stage malaria vaccine (AdFalciVax). The vaccine was developed by Indian Council of Medical Research (ICMR) and partners. It targets Plasmodium falciparum before it enters the bloodstream to prevent transmission. The vaccine is affordable, stable, scalable, and effective for over 9 months at room temperature.
4. Where was India’s first private large-format additive manufacturing facility for aerospace and rocket systems launched by Agnikul Cosmos?
[A] Kolkata
[B] Hyderabad
[C] Chennai
[D] Bengaluru
Show Answer
Correct Answer: C [Chennai]
Notes:
Agnikul Cosmos, a spacetech startup, commissioned India’s first private large-format additive manufacturing facility for aerospace and rocket systems. The facility was launched at the Indian Institute of Technology Madras (IIT-M) Research Park in Chennai. It combines design, simulation, 3D printing, post-processing, and testing under one roof to speed up development and cut costs. For the first time in India, aerospace parts up to 1 metre in height can be 3D-printed.
5. Lecanemab drug, that was recently seen in news, is used to treat which disease?
[A] Multiple Sclerosis
[B] Tuberculosis
[C] Alzheimer’s Disease
[D] Huntington’s Disease
Show Answer
Correct Answer: C [Alzheimer’s Disease]
Notes:
Australia recently approved Lecanemab for early-stage Alzheimer’s disease. Dementia causes progressive memory and thinking problems and is now Australia’s leading cause of death. Alzheimer’s disease accounts for 60-80% of dementia cases. Lecanemab is a monoclonal antibody drug that targets amyloid proteins in the brain. It aims to slow disease progression by tackling the cause of Alzheimer’s, not just symptoms. The drug works by using antibodies to mark amyloid for removal by brain immune cells, preventing toxicity to brain cells.
6. Where was India’s first Artificial Intelligence (AI) Centre of Excellence for Public Good launched?
[A] Bengaluru, Karnataka
[B] Pune, Maharashtra
[C] Hyderabad, Telangana
[D] Visakhapatnam, Andhra Pradesh
Show Answer
Correct Answer: D [Visakhapatnam, Andhra Pradesh]
Notes:
On October 13, 2025, TechBharat Research Foundation (TBRF) and Google Cloud India launched India’s first Artificial Intelligence (AI) Centre of Excellence (CoE) for Public Good in Visakhapatnam, Andhra Pradesh (AP). The initiative was supported by the Government of Andhra Pradesh, particularly its Department of Information Technology, Electronics & Communications (IT, E&C). A Memorandum of Understanding (MoU) was signed between the Government of Andhra Pradesh and TechBharat Research Foundation (TBRF) for setting up and operating the CoE. TBRF will lead the CoE as a hub for applied AI research and public service solutions. Google Cloud India will provide cloud infrastructure, Gemini AI models, tools, mentorship, and market support.
7. Amoebic Meningoencephalitis, that was recently seen in the news, affects which part of the body?
[A] Kidneys
[B] Brain
[C] Heart
[D] Lungs
Show Answer
Correct Answer: B [Brain]
Notes:
Kerala reported another death from Amoebic Meningoencephalitis (Primary Amebic Meningoencephalitis, PAM), raising the 2025 toll to 27 cases. Primary Amebic Meningoencephalitis is a rare, fatal brain infection caused by the free-living amoeba Naegleria fowleri, known as the “brain-eating amoeba.” Infection occurs when contaminated freshwater enters the nasal cavity, allowing the amoeba to reach the brain via the olfactory nerve. It is found in warm freshwater and soil, especially lakes, rivers, hot springs, and unchlorinated pools.
8. Which African country reported an outbreak of the Lassa fever in 2025?
[A] Botswana
[B] Ghana
[C] Mali
[D] Nigeria
Show Answer
Correct Answer: D [Nigeria]
Notes:
In Nigeria, the Lassa fever outbreak has claimed 172 lives since January 2025. The Nigeria Centre for Disease Control and Prevention (NCDC) reported 924 confirmed cases out of 8,041 suspected cases till October 2025. The case fatality rate stands at 18.6%, higher than 17% in 2024. The most affected age group is 21 to 30 years. The outbreak is worsened by poor sanitation, low awareness, and delayed treatment. Lassa fever is a viral haemorrhagic illness caused by the Lassa virus from the Arenavirus family. Infection spreads through food or household items contaminated by urine or faeces of infected Mastomys rats. The World Health Organization (WHO) stresses early diagnosis and quick treatment for survival.
9. What is the natural host reservoir of the Nipah Virus, that was recently seen in news?
[A] Rodents
[B] Fruit bats
[C] Mosquitoes
[D] Pig
Show Answer
Correct Answer: B [Fruit bats]
Notes:
The Indian Council of Medical Research (ICMR) has invited Expressions of Interest (EoI) from organisations and manufacturers to develop monoclonal antibodies (mAbs) against Nipah viral disease. Nipah virus is a zoonotic pathogen from the Paramyxoviridae family. In India and Bangladesh, the Bangladesh clade (NiV-B) is dominant, known for high virulence and human-to-human transmission. The fatality rate ranges between 40% and 75%, depending on treatment and outbreak control. Fruit bats (flying foxes) are the natural reservoirs, spreading the virus to humans and animals like pigs, goats, and cats.
10. The Copernicus Sentinel-1D Earth-Observation Satellite (EOS) was launched by which space agency?
[A] National Aeronautics and Space Administration (NASA)
[B] Indian Space Research Organisation (ISRO)
[C] European Space Agency (ESA)
[D] Japan Aerospace Exploration Agency (JAXA)
Show Answer
Correct Answer: C [European Space Agency (ESA)]
Notes:
In November 2025, the European Space Agency (ESA) and Arianespace launched the Copernicus Sentinel-1D Earth Observation Satellite (EOS) to Low Earth Orbit (LEO) aboard the Ariane 6 rocket from the Guiana Space Centre, French Guiana. The mission, designated VA265, marked a key step in strengthening Europe’s autonomous access to space and Earth observation capability. It is the fourth and final satellite of the first-generation Copernicus Sentinel-1 constellation, completing Europe’s radar imaging network.