1. Which institute discovered that protein p47 acts as a “mechanical chaperone”, enhancing protein stability under mechanical stress?
[A] Indian Institute of Science (IISc), Bengaluru
[B] S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata
[C] National Chemical Laboratory (NCL), Pune
[D] Centre for Cellular and Molecular Biology (CCMB), Hyderabad
Show Answer
Correct Answer: B [S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata]
Notes:
Researchers at S. N. Bose National Centre for Basic Sciences (SNBNCBS) discovered protein p47’s new role as a “mechanical chaperone.” P47 is a cofactor protein known for assisting p97 in protein trafficking, degradation, and membrane fusion. Study revealed p47 boosts mechanical efficiency of protein extraction from endoplasmic reticulum (ER) to cytoplasm. It stabilizes polypeptides under stress, guides them through pores, prevents misfolding, and improves translocation. This is the first single-molecule evidence of autonomous, force-dependent chaperone-like activity by p47. Discovery opens new therapeutic possibilities for diseases linked to protein instability.
2. Which country has launched EnteroMix, a new mRNA-based cancer vaccine?
[A] Russia
[B] China
[C] India
[D] Australia
Show Answer
Correct Answer: A [Russia]
Notes:
Russia has launched EnteroMix, a new mRNA-based cancer vaccine, reported to show 100 percent efficacy in early trials. It was developed by the National Medical Research Radiology Centre (NMRRC) and Engelhardt Institute of Molecular Biology under the Russian Academy of Sciences. The launch took place at the St Petersburg International Economic Forum (SPIEF 2025) and shared globally via Sputnik news service. The vaccine targets colorectal cancer first, with versions in development for glioblastoma and melanoma. EnteroMix uses four harmless viruses to attack cancer cells and boost immune defence. Russian Federal Medical and Biological Agency (FMBA) confirmed its safety for repeated use and personalised RNA-based tailoring.
3. Which institute has developed cholesterol-based nanomaterials for quantum technologies and spintronic applications?
[A] Indian Institute of Technology, Delhi
[B] Institute of Nano Science and Technology, Mohali
[C] Indian Institute of Technology, Bombay
[D] Tata Institute of Fundamental Research
Show Answer
Correct Answer: B [Institute of Nano Science and Technology, Mohali]
Notes:
Cholesterol, a fat-like substance, can control the spin of electrons, a quantum property crucial for next-generation spintronic devices. Spintronics uses electron spin to develop energy-efficient electronics and bioelectronic devices. Scientists from the Institute of Nano Science and Technology (INST), Mohali, under the Department of Science and Technology (DST), developed cholesterol-based nanomaterials for spintronic and quantum applications. Cholesterol’s intrinsic handedness (chirality) and flexibility allow precise control over molecular properties. This innovation could enable energy-efficient memory chips and greener quantum technologies.
4. What is the name of the asteroid recently confirmed as Earth’s latest quasi-satellite in September 2025?
[A] Victoria 2025
[B] Flora 2025
[C] 2025 PN7
[D] Cardea
Show Answer
Correct Answer: C [2025 PN7]
Notes:
Astronomers discovered asteroid 2025 PN7 in September 2025 as Earth’s latest quasi-satellite. ‘Quasi’ means almost; the asteroid is not gravitationally bound but orbits the Sun in resonance with Earth. It is an Arjuna-class near-Earth asteroid, named after Mahabharata’s Arjuna. 2025 PN7 orbits the Sun while staying close to Earth and will remain in this quasi-satellite state for approx 128 years. It was first spotted on August 2, 2025, by Panoramic Survey Telescope and Rapid Response System 1 (Pan-STARRS 1) in Hawaii.
5. Which institute in Delhi has launched the city’s first central tissue bank for bone grafting in dental surgeries?
[A] All India Institute of Medical Sciences (AIIMS)
[B] Maulana Azad Medical College
[C] Lady Hardinge Medical College
[D] Vardhman Mahavir Medical College
Show Answer
Correct Answer: B [Maulana Azad Medical College]
Notes:
Maulana Azad Medical College (MAMC), Delhi, launched the city’s first Central Tissue Bank for bone grafting in dental surgeries. The facility was inaugurated by Delhi Health Minister Dr Pankaj Kumar Singh. Bone grafting helps reverse jawbone loss and supports dental implants, dentures, and tissue regeneration. The tissue bank provides ready access to high-quality bone and soft tissue grafts, reducing cost and addressing limited availability.
6. What is Asphyxia, which recently caused deaths in the TVK rally stampede at Velusamypuram?
[A] Excessive bleeding due to injury
[B] Condition when the body does not get enough oxygen
[C] Poisoning from contaminated food
[D] None of the Above
Show Answer
Correct Answer: B [Condition when the body does not get enough oxygen]
Notes:
The death toll in the stampede at Tamilaga Vetri Kazhagam (TVK) rally in Velusamypuram has risen to 41. Doctors reported most fatalities were due to compressive asphyxia caused by crowd crush. Asphyxia occurs when the body does not get enough oxygen. Respiration moves oxygen into the lungs and circulates it via blood to all body cells, while carbon dioxide is removed. Lack of oxygen can cause unconsciousness or death. Compressive asphyxia happens when an external force prevents chest expansion, crushing the lungs and stopping breathing. This can occur in crowded situations or from a person’s weight on the chest.
7. Which country has launched Southeast Asia’s first Coral Larvae Cryobank, a major step to protect marine biodiversity?
[A] China
[B] Thailand
[C] Indonesia
[D] Philippines
Show Answer
Correct Answer: D [Philippines]
Notes:
The Philippines has launched Southeast Asia’s first Coral Larvae Cryobank, a major step to protect marine biodiversity. The cryobank is a scientific facility that freezes and stores coral larvae at ultra-low temperatures. It preserves the genetic material of corals for future reef restoration and scientific research. The facility acts like a “genetic seed vault” for corals to help safeguard biodiversity from climate change and coral bleaching. The project is part of the Coral Research and Development Accelerator Platform (CORDAP). Philippines, Taiwan, Indonesia, Malaysia, and Thailand are jointly participating in this regional conservation effort.
8. What kind of disease is Crohn’s disease that was recently seen in news?
[A] A respiratory disorder
[B] Autoimmune neurological disorder
[C] A heart disease
[D] A chronic inflammatory bowel disease
Show Answer
Correct Answer: D [A chronic inflammatory bowel disease ]
Notes:
Recent research shows that eating diets high in Ultra Processed Foods (UPFs) can worsen gut inflammation and increase Crohn’s disease flare-ups. Crohn’s Disease is a chronic Inflammatory Bowel Disease (IBD) that causes swelling and irritation in the digestive tract. It usually affects the small intestine and the beginning of the large intestine. Inflammation can spread deep into the bowel layers, causing pain and serious complications. Common symptoms include diarrhea, abdominal cramps, and weight loss. It mostly develops between ages 20 and 29. The exact cause is unknown but may involve genes, immune reactions, and the microbiome. There is no cure, but treatment helps control symptoms and maintain remission.
9. Where was India’s first Artificial Intelligence (AI) Centre of Excellence for Public Good launched?
[A] Bengaluru, Karnataka
[B] Pune, Maharashtra
[C] Hyderabad, Telangana
[D] Visakhapatnam, Andhra Pradesh
Show Answer
Correct Answer: D [Visakhapatnam, Andhra Pradesh]
Notes:
On October 13, 2025, TechBharat Research Foundation (TBRF) and Google Cloud India launched India’s first Artificial Intelligence (AI) Centre of Excellence (CoE) for Public Good in Visakhapatnam, Andhra Pradesh (AP). The initiative was supported by the Government of Andhra Pradesh, particularly its Department of Information Technology, Electronics & Communications (IT, E&C). A Memorandum of Understanding (MoU) was signed between the Government of Andhra Pradesh and TechBharat Research Foundation (TBRF) for setting up and operating the CoE. TBRF will lead the CoE as a hub for applied AI research and public service solutions. Google Cloud India will provide cloud infrastructure, Gemini AI models, tools, mentorship, and market support.
10. The new crop varieties ‘Pant Urd-13, Pant Urd-14, Pant Matar 554, and Pant Jau 1106’ were launched in which state?
[A] Gujarat
[B] Uttarakhand
[C] Maharashtra
[D] Uttar Pradesh
Show Answer
Correct Answer: B [Uttarakhand]
Notes:
On October 12, 2025, Uttarakhand Chief Minister Pushkar Singh Dhami inaugurated newly developed pulse and barley varieties at the 118th All India Farmers Fair and Agricultural Industry Exhibition held at GB Pant University of Agriculture and Technology (GBPUAT) in Uttarakhand. The varieties were developed by GBPUAT students to improve crop productivity and farmer income. Pant Urd-13 and Pant Urd-14 are improved urdbean (black gram) varieties with higher yield and better disease resistance. Pant Matar 554 is a high-yielding pea variety designed to enhance farmers’ earnings. Pant Jau 1106 is a new barley variety introduced to diversify crop options for farmers in the region.