CALM2

CALM2 is a gene that is responsible for the production of calmodulin, a protein that regulates the transport of calcium ions in the cardiac muscle cells (cells of the heart muscles). Calcium ions play a key role in the ‘excitation-contraction coupling’ process in the heart. Mutations in the CALM2 gene can cause cardiac arrests, which in turn can lead to sudden death. Recently, scientists highlighted the presence of CALM2 G114R- a genetic variant of the CALM2 gene in the Folbigg children.