Bharat Cancer Genome Atlas

February 4, 2025

The Indian Institute of Technology Madras recently launched the Bharat Cancer Genome Atlas (BCGA). This initiative aims to enhance cancer research in India. It addresses the under-representation of Indian genetic data in global cancer studies. The launch comes ahead of World Cancer Day and marks the increasing cancer incidence in the country.

Overview of the Bharat Cancer Genome Atlas

The BCGA is a comprehensive database of genetic variants linked to breast cancer in India.
It collects data from breast cancer patients across the country.
The goal is to identify specific biomarkers for early detection and develop targeted treatment strategies.

Significance of the Initiative

This initiative is crucial for understanding the unique genetic landscape of Indian cancers. The database will aid in the identification of cancer-specific biomarkers. It will also facilitate the development of diagnostic kits and targeted therapies tailored to the Indian population.

Research and Collaboration

IIT Madras collaborated with Karkinos Healthcare and Chennai Breast Clinic for this project. The research involved whole exome sequencing of 480 breast cancer patient samples. This collaboration ensures a robust analysis of genetic variants and enhances the quality of the research.

Data Accessibility and Future Implications

The BCGA database is publicly accessible. Researchers and clinicians can use it to study cancer genomics across various types. The database aims to encourage a collaborative environment for cancer research in India.

Personalised Medicine Approach

The initiative supports the shift towards personalised medicine in India. By understanding individual genetic profiles, healthcare providers can make informed decisions. This approach may improve treatment outcomes and patient care.

Current Cancer Statistics in India

According to the Indian Council of Medical Research, cancer incidence is rising. One in nine individuals in India is likely to develop cancer in their lifetime. The National Cancer Registry Programme reports a 12.8% annual increase in cancer cases since 2022.

Potential for Early Detection

The BCGA aims to enable early detection of breast cancer. By identifying mutations before cancer develops, preventive measures can be implemented. This proactive approach could reduce cancer-related morbidity.

Cost-Effective Diagnostic Solutions

The initiative also focuses on developing affordable diagnostic kits. The experience from the COVID-19 pandemic shows that costs can be reduced . This could lead to mass-scale screening for breast cancer in the Indian population.

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